In early 2019, the University of Adelaide was ranked No. 1 for entrepreneurship education and engagement in Australia (Maritz, 2019), and the Adelaide Business School’s research and education activities was instrumental to this ranking. Although other universities may claim to be entrepreneurial, none has the foundational and structural capacity of the University of Adelaide. We have a distinct entrepreneurial pedigree. The University is an influential stakeholder in the entrepreneurship ecosystem, creating graduates who are equipped with the dynamic skill-set required to thrive in today’s employment landscape. We do this by developing entrepreneurial mindsets and skills through our entrepreneurship and innovation courses, both core and elective, across all disciplines at all levels of study. In addition, we provide platforms that supporting staff with their entrepreneurial endeavours. Furthermore, its influence is recognised regionally within South Australia, and internationally. Influence on both policy and practice is particularly evident in the progressive role the University has played over more than two decades. The University’s strategic commitment to entrepreneurship began at its inception and has been an organisational cornerstone throughout its history as a disruptive and innovative institution. This commitment is evident in its strategy, leadership and operations. We have been a leader in our field, particularly with regard to incorporating entrepreneurship and innovation in our course design, research commercialisation, and community and business engagement. We were the first to appoint a Pro Vice Chancellor (Entrepreneurship) and continue to lead the way in entrepreneurship education and engagement.