For the University of Coimbra, a 732-year-old institution, being entrepreneurial means that we have duty of start new programs, aimed at solving our own necessities, being able to identify and clear settle the way to solve different problems. The technology transfer office of the University of Coimbra - UC Business- is responsible for implementing the entrepreneurship strategy of the whole institution, which includes design and execution of entrepreneurial programs, either directed to students, researchers and administrative staff, reinforcing competencies throughout all university. In order to increase the success of entrepreneurial projects, we have organized working sessions involving all the entrepreneur and innovation teachers, that give classes in more the 37 disciplines, on 6 of the 8 university faculties, preparing several hundreds of students. Furthermore, the university has developed a long-term strategy that includes 5 specialized incubators and 1 business accelerator, where startups and spin-offs can easily be installed and supported by specialized technicians. Furthermore, throughout a national funded project, InovC+, coordinated by University of Coimbra, we aim to increase the technology transfer capacity of all higher education public institution of the central regions of Portugal, some of which without a technology transfer office. Thus, it is necessary to share experience and help other institutions, in order to ensure a best regional development. In a different domain, the Rector of University of Coimbra is the 2022 President of the MetaRedX Portugal. This collaborative network promotes the Entrepreneurship Units of Higher Education Institutions, across Portugal, Spain, Brazil, Mexico, Colombia, Peru and Argentina, as a vehicle to startups creation in Academia.